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Metformin Associated Lactic Acidosis Pdf Download

 
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MessagePosté le: Jeu 1 Sep - 04:40 (2016)    Sujet du message: Metformin Associated Lactic Acidosis Pdf Download Répondre en citant




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Metformin Associated Lactic Acidosis Pdf Download


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Guo PY, Storsley LJ, Finkle SN (2006) Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin. UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). View Article PubMed/NCBI Google Scholar 25. Metformin associated lactic acidosis Practice Lesson of the Week Metformin associated lactic acidosis BMJ 2009; 339 doi: (Published 16 September 2009) Cite this as: BMJ 2009;339:b3660 Article Related content Metrics Responses Peer review Emma Fitzgerald, specialist trainee year 2 in anaesthetics 1, Stephen Mathieu, specialist registrar in anaesthetics and intensive care medicine1, Andrew Ball, consultant in anaesthesia and intensive care medicine11Dorset County Hospital, Dorchester, Dorset DT1 2JYCorrespondence to: E Fitzgerald zcharm6{at}hotmail.comAccepted 30 March 2009Dehydration in patients taking metformin can lead to metformin associated lactic acidosis, a potentially fatal conditionMetformin, a dimethylbiguanide, is a widely used oral antihyperglycaemic drug used in the long term treatment of type 2 diabetes mellitus. This institutional review board waived the need for consent given the retrospective design of the project. Table 1 summarizes the demographics and laboratory data of the seven MALA cases.

However, the concentration of metformin in erythrocytes may be more useful, since it better reflects tissue accumulation [19]. 1992;152:23332336. Thanks for your help! Flow rate Is the Subject Area "Flow rate" applicable to this article? Yes No Thanks for your feedback. She was intubated, ventilated and administered massive fluid resuscitation immediately. Although metformin associated lactic acidosis is a rare condition, with an estimated prevalence of one to five cases per 100000 population,3 it has a reported mortality of 30-50%.4 Prognosis seems to be unrelated to plasma metformin concentration or lactate level.5We present a report on a patient with type 2 diabetes who was receiving long term treatment with metformin and developed severe metformin associated lactic acidosis after dehydration, which resulted in renal impairment and consequent accumulation of metformin. Lactic acidosis Is the Subject Area "Lactic acidosis" applicable to this article? Yes No Thanks for your feedback. Second, metformin has a large volume of distribution (3.1 l/kg) secondary to intracellular penetration [29].

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